A new intravenous anesthetic, Propanidid, a eugenol derivative was clinically evaluated on 30 gynecological outpatients and 55 parturients.
The first dose was graded in each three groups varying 5 to 10mg/kg and adding further dose when necessary. Although,with the incrementof the dosage, respiratory changes were observed more frequently, associated with prolongation in the duration of anesthesia, occurenee of side effects and the time needed for recovery were the same.
The depth of anesthesia was satisfactory for minor gynecological procedures but operative delivery had to be performed in most of the parturients due to diminished uterine contractions and bearning-down power.
The intravenous administration of the agent yielded hyperventilation in many cases followed by hypoventilation or appnea of shorter duration in some cases. However, gradual and spontaneous disappearance of this change was a rule.
During and after the use of this agent there were minor untoward reactions such as involuntary movements, dizziness, headache, nausea, vomiting and shivering.
|